Based on some tips Michele provided, below is an updated itinerary for a mid October 2 week trip my husband and I are taking to Ireland. Would appreciate any comments/suggestions, particularly relating to some specific question I've noted below.

1. Fly into Dublin. Stay two nights at Fitzwilliam Guesthouse.  Have a day and a morning in Dublin.
2.  Spend one night in Trim to see Newgrange
3. Drive to Galway, stay 2 nights to see town and surrounding areas. Staying at Prague B and B.
4. On to Dingle, staying a 2 nights at the Towerview B and B
5. On to Kilkenny to stay one or two nights.  See Rock of Cashell on the way.  Also see the Famine Ship.
6. On to Wexford to see town and a day or so of the Fringe Art Festival. Trying to decide between Rosemount B and B and Blue Door. Any experience with either of those?
7. Leave early and see Glendolough and Powerscourt. Can we see both those sights in one day?  Back to Dublin Airport for evening flight. 

Will we need any advance reservations at any of the major sights in mid October?

Thanks for any comments or suggestions.